Atopic disease is an increasing problem. Eczema affects 10-20% of young children, and 33-37% of children with eczema are food allergic. Among other factors, nitric oxide (NO) is thought to play a role in eczema and food allergy. Following the atopic march, pproximately 80% of children with atopic eczema will become sensitized to aeroallergens and develop asthma and/or allergic rhinitis. Skin prick test is used for investigating sensitization and is considered a safe method. However, systemic allergic reactions may appear when the test is performed. In diagnosing food allergy and for evaluating achievement of tolerance, the oral food challenge is the method of choice, and the double-blind placebocontrolled fashion is ‘the gold standard’. Skin prick test: We examined six cases of generalized allergic reactions in connection with skin prick testing in order to identify risk factors, and thereby increase safety, and we investigated the necessity of performing skin prick tests in duplicate. We found that all six children…
Contents
INTRODUCTION
The Atopic March
Risk factors in atopic disease
Prevention of atopic disease
Eczema
Genetics
Skin pathology
Immunopathology
Clinical features of atopic eczema
Diagnostic criteria for atopic eczema
SCORAD
Treatment of eczema
Gastrointestinal inflammation, eczema and nitric oxide
Food Allergy
Food allergy mechanisms
Clinical manifestations in food allergy
Food allergy and its effect on intake, growth and quality of life
Diagnosing food allergy
Skin prick test (SPT)
Specific IgE in sera
Oral food challenge ñ standardized open and
double-blind placebo controlled (DBPCFC)
Treatment of food allergy
Appendix 1, statistics
ACKNOWLEDGEMENTS
REFERENCES
Author: Devenney, Irene
Source: Linköping University
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