Hepatitis C virus infection

The hepatitis C virus (HCV) was recognized in 1989. HCV hepatitis C virus was transmitted via transfusion of blood/blood products, however injection drug use has become the commonest path of transmission. The infection is generally asymptomatic however results in being serious in approximately 75%, and in 20 years 15-25% develops liver cirrhosis, with a danger for liver failure and liver cancer. Hepatitis C virus HCV has additionally been linked with lymphoproliferative problems.The purpose of this report was to study deaths and mortality in a national, population-based cohort of HCV-infected individuals. The research population was comprised of all persons with a diagnosed HCV-infection registered in the national surveillance database. This file was connected to other national registers to get details of emigration, deaths, cancers, and inpatient care. All personal identifiers had been deleted prior to analysis. In Paper I the standard incidence ratios (SIR) for Hodgkin’s and non-Hodgkin’s lymphoma (NHL), multiple myeloma, acute and chronic lymphatic leukaemia, and thyroid cancer were analyzed. In the HCV-cohort (n: 27,150) there was clearly a doubled risk for NHL and multiple myeloma in patients infected in excess of Fifteen years, in contrast to the general population (age-, sex- and calendar-year specific incidence rates). The outcomes strengthened these earlier controversial associations. The SIR along with the overall risk for primary liver cancer were estimated in Paper II. In the hepatitis C virus HCV-cohort (n: 36,126) the people infected for more than 25 years had a more than 40 times increased risk for liver cancer in contrast to the general population…


Historical aspects on hepatitis C virus (HCV) infection
HCV virology
Diagnosis of HCV infection
Epidemiology and routes of transmission
The natural course of HCV infection
Extra-hepatic manifestations
Health care resource use
Therapy for HCV infection
Study population
Linkage to other registers
Modelling date of infection
HCV, non-Hodgkin’s lymphoma and multiple myeloma – Paper I
Hepatitis C virus HCV and hepatocellular carcinoma – Paper II
HCV and mortality – Paper III
Hepatitis C virus HCV and inpatient care – Paper IV

Source: Orebro University

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