Microbe-induced apoptosis in phagocytic cells and its role in innate immunity

Apoptosis, or programmed cell death, is a controlled process by which aged or damages cells are eliminated in multicellular organisms. Neutrophils, short-lived phagocytes of the innate immune system, are highly equipped effectors that can sense, locate, ingest and kill bacterial pathogens. Inflammatory mediators and the presence of bacterial products at the foci of infection regulate the function and life span of these cells. Modulation of neutrophil apoptosis…


Immediate response to infection
Adhesion and migration
Phagocytosis and intracellular killing
Neutrophils and inflammation
Elimination of neutrophils
Morphology of apoptosis
Bcl-2 family
Initiation of apoptosis
Regulation of apoptosis
Apoptosis in neutrophils
Apoptosis modulation by microbes
Type-ІІІ secretion system
Clearance of apoptotic cells
Cell surface changes and recognition
Cofactors for recognition
Consequences of apoptotic cells clearance
Aim of the dissertation
Results & Discussion………..

Author: Blomgran, Robert

Source: Linköping University

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