Due to the failure up to now to find efficient remedy for patients with advanced stages of melanoma, growing initiatives are already made to find prognostic factors identifying patients in the risk zone for progression of metastasis. This dissertation researches the prognostic powers of some chosen serological and immunohistochemical biomarkers. In the first and second analysis, patients operated on for localized malignant melanoma had been looked at concerning the prognostic effect of angiogenic serological markers and circulating levels of S100. We figured that the S100 assays, especially S100BB, are potential biomarkers in patients with malignant melanoma, linked to both survival and illness free survival. But, no such conclusion could possibly be drawn from the initial study, where we found no correlation to survival and investigated angiogenic markers…
Contents: Prognostic Factors in Malignant Melanoma
Introduction
Epidemiology
Pathology
Risk factors
Diagnosis
Symptoms
Diagnostic investigations
Staging
Treatment
Surgery
Sentinel lymph node biopsy
Surgery for metastases
Chemotherapy
Biological treatment
Chemoimmuno therapy
Radiation
Prognosis
Localized melanoma: Stage I and II
Regional metastases: Stage III
Distant metastases: Stage IV
Blood tests and serum markers
Angiogenesis
Investigated markers
S100
Galectin-1
TRP-1
Discs Large Homolog 5 (Dlg5)
Syntaxin 7 (STX7)
SOX 10
Ki67
Melan-A
Aims of the thesis
Patients and Methods…
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