Sorting nexin 9 in clathrin-mediated endocytosis

Clathrin-mediated endocytosis is a process by which cells can internalise diverse molecules such as nutrients, antigens and signalling-surface receptors. The creation of clathrin-coated vesicles demands interplay between the plasma membrane lipids, cargo molecules and the proteins that build up the coat.This thesis deals with the identification and characterisation of sorting nexin 9 (SNX9) as a novel component of the endocytic machinery…

Contents

1. INTRODUCTION
2. ADAPTOR PROTEIN COMPLEXES
3. CLATHRIN
4. ENDOCYTOSIS
5. CLATHRIN-MEDIATED ENDOCYTOSIS
5.1 Structure and function of AP-2
5.2 Plasma membrane recruitment
5.3 Accessory protein network
5.4 Cargo selection
5.5 Membrane curvature
5.6 Dynamin and vesicle fission
5.7 Role of actin in endocytosis
5.8 Vesicle uncoating
5.9 Regulation of coat formation
6. SORTING NEXIN
6.1 SH3 domains
6.2 PX domains….

Author: Lundmark, Richard

Source: Umea University

projects, dissertation, thesis, project report

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