Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases

Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary…


The type I interferon system
Type I IFN producers
Type I IFN inducers and induction mechanisms
Signaling from RIG-I-like proteins and Toll-like receptors
Regulation of type I IFN induction
Type I IFN signaling
Type I IFN effects
Autoimmune diseases and the type I IFN system
General about autoimmune diseases
Type I IFN therapy and autoimmunity
Systemic lupus erythematosus
Sjögren’s syndrome
The type I IFN system in other autoimmune diseases
The present investigation
General aims
Specific aims
Material and methods
Cell preparations
Induction experiments
Identification of IFN-D-producing cells
Results and discussion…

Author: Lövgren, Tanja

Source: Uppsala University Library

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project reports, dissertation, thesis

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