S-nitrosogluthatione is surely an endogenous substance, found at decreased levels in the lungs of CF patients and was not too long ago discovered to induce mature CFTR in airway epithelial CF cell lines. We reveal that S-nitrosoglutathione in physiological concentrations raises the
The cystic fibrosis transmembrane conductance regulator CFTR, a cAMP activated chloride channel in the apical membrane of epithelial cells, is defective in patients with cystic fibrosis CF. Research efforts are focused on chloride channel function in order to find a cure for the disease.
Airway epithelial damage is commonly found in asthma patients. Epithelial damage was investigated with special reference to contacts between epithelial cells. Eosinophils, common in allergic asthma, secrete cationic proteins, particularly major basic protein (MBP). The effect of poly-L-arginine, an analogue of MBP,
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