Anandamide (AEA) is surely an endogenous fatty acid that triggers the same cannabinoid receptors as tetrahydrocannabinol, the psychoactive substance in marijuana. In vivo, anandamide exerts numerous actions including effects upon inflammation and pain. Nevertheless, AEA has a brief time period of action
Neuroblastoma is a childhood cancer which arises from neuroblasts in the peripheral nervous system. Neuroblastoma show substantial heterogeneity regarding location, responsiveness to treatment and prognosis. Due to the fact current therapy requires drugs with likelihood of severe negative effects in the growing
Grade 2 gliomas are malignant brain tumours affecting otherwise healthy adults. Although the long-term prognosis is poor, many patients are well and may have a high quality of life for several years. There is, however, a large variability in the natural course
Hodgkin lymphoma (HL) is characterised histologically by a minority of malignant Hodgkin and Reed-Sternberg (HRS) cells surrounded by benign cells, and clinically by a relatively good prognosis. The treatment, however, leads to a risk of serious side effects. Knowledge about the biology
In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell