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Design and Application of Software Sensors in Batch and Fed-batch Cultivations during Recombinant Protein Expression in Escherichia coli

The aim of the current project was to develop software sensors which probe for important state parameters in batch and fed-batch cultivations and which enable to control processes in a more advanced and effective way. Software sensors are a potent tool to improve biotechnological real time process monitoring and control. In the current project, algorithms for six partly novel, software sensors were established and tested in a microbial reactor system. Eight batch and two fed-batch runs were carried out with ...

Project category: Biological Engineering