The ecological significance of sexual reproduction in peat mosses (Sphagnum)

This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal.The crystal structures of carbonic anhydrases (CA) Rv1284 and Rv3588c have been determined to 2.0 and 1.7 Å resolution, respectively. Rv3588c, in contrast to Rv1284, is an active β-CA that shows two different active site conformations and pH-dependent oligomerization states.Rv1295 is an active threonine synthase with an unusually high pH optimum; the structure has been solved to 2.5…


Material and methods
Results and discussion
Agenda for further research

Author: Suarez Covarrubias, Adrian

Source: Uppsala University Library

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