This thesis describes the Chandler loop, which makes it possible to conduct studies in vitro of molecular and cellular interactions between whole blood and stents. It was possible to monitor activation and inhibition of the cascades systems, leukocytes and platelets by combining different platelet inhibitors and heparin coating of stents…
Contents
Introduction
Chapter 1. THROMBOSIS AND HAEMOSTASIS
1.1. PLATELET GRANULES
1.2. CYTOSKELETON
1.3. SCRAMBLING
1.4. PLATELET RECEPTORS
1.4.1. Platelet fibrinogen receptor (DIIbE3)
1.4.2. GPIb-IX-V complex
1.4.3. P-selectin
1.4.4. ADP receptors
1.4.5. Collagen receptors
1.4.6. Thrombin receptors
1.4.7. Other receptors
1.4.8. Platelet signalling
1.5. PRIMARY HAEMOSTASIS
1.5.1. Adhesion
1.5.2. Activation
1.5.3. Aggregation
1.5.4. Microparticle formation
1.6. SECONDARY HAEMOSTASIS
1.6.1. Extrinsic pathway
1.6.2. Intrinsic pathway
1.6.3. The common pathway
1.6.4. Clot retraction
1.6.5. Down regulating mechanisms
1.7. FIBRINOLYSIS
1.8. COMPLEMENT
1.8.1. C-1-esterase inhibitor
1.9 NEW CONCEPTS OF COAGULATION
Chapter 2. PRINCIPLES OF ANTITHROMBOTIC TREATMENT
2.1. PLATELET INHIBITORS
2.1.1. Aspirin
2.1.2. ADP-receptor antagonists
2.1.3. Fibrinogen receptor antagonists
2.1.4. Dipyridamole
2.2. COAGULATION INHIBITORS
2.2.1. Warfarin
2.2.2. Heparins
2.2.3. Thrombin inhibitors
2.2.4. Factor Xa inhibitors
2.2.5. Factor VIIa/Tissue factor complex
Chapter 3. STUDY AIMS
Chapter 4. MATERIAL AND METHODS
4.1. Chandler loop
4.2. Stents
4.3. Heparin coating
4.4. Flow cytometry
4.5. Additional
4.6. Donors
4.7. Collection
4.8. Clinical study
Paper IV (the flow cytometry study)
Paper V (inflammatory parameters)
4.9. Statistical analysis…
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Author: Christensen, Kjeld
Source: Uppsala University Library
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Keywords: projects, dissertation, thesis, project report