Psoriatic arthritis (PsA) is an inflammatory joint disease related to psoriasis. PsA has a heterogeneous structure, indicated by various manifestations like mild mono-oligoarthritis or very severe, erosive and damaging polyarthritis. Measurable inflammatory activity isn’t necessarily prominent. The aetiology is not known but
Coeliac disease (CD) is considered to be the result of a complex interplay of intrinsic (genetic) factors and variable extrinsic (environmental) factors. The complex background of CD explains its wide spectrum of clinical manifestations. For a very long time CD was considered more or less a disease of childhood, which was extremely rare in adults. Nowadays we know that CD is one of the most common food intolerance disorders.
In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell