Speciation is the procedure explaining the development of new species and is at the heart of evolutionary biology. In accordance with the biological species concept only reproductively isolated types are considered good species. This dissertation is designed at identifying evolutionary processes which
Aquatic ecosystems display complex spatially-varying patterns of growth and decay. These patterns are produced by the interaction of numerous physical and biological processes that result in characteristic scales of patchiness with important ecological consequences… Contents Chapter 1: General Introduction 1.1 The Issue
Glutathione S-transferases (GSTs) are an important family of xenobiotic biotransforming enzymes that can make toxicity tests variable. Daphnia magna is commonly used in ecotoxicology testing because they are easy to culture, have a short life cycle, and reproduce by parthenogenesis.
Composite collections of channel catfish (Ictalurus punctatus), white perch (Morone americana), their prey items (forage fish and epibenthos), and surficial sediment had been gathered in the Delaware River estuary in Fall 2001 and Spring 2002 to evaluate polychlorinated biphenyl (PCB) deposition and
Comparative reports of bacterial genomics, now counting in the 100s, produce enormous amounts of information. To be able to support an organized and successful strategy to genomic analyses, a database powered program with graphic visualization of genomic qualities was created – GenComp. The application was employed on studies of obligate intracellular bacteria.
This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary
Although they have improved the health of countless numbers of humans and animals, antibiotics have been losing their effectiveness since the beginning of the antibiotic era. The use of antibiotics in raising food animals has contributed significantly to the global pool of
The large majority of the currently used drugs are small molecules that interact with proteins. Understanding protein-ligand recognition is thus central to drug discovery and design. This has stimulated the development of chemogenomics and proteochemometrics (PCM) that take target information… Contents 1.
Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation.The aim of this work was to
The role of infauna on permeable sediment processes is poorly understood due to methodological limitations and a lack of empirical data. The interactions among porewater flows, sediments, and biogenic structures present a physically and … Contents Chapter 1: Executive Summary: Infaunal Effects