Polypeptide-Based Nanoscale Materials

Self-assembly has surfaced as a promising way of fabrication of novel hybrid materials and nanostructures. The work offered in this dissertation has been centered on creating nanoscale materials based on synthetic de novo designed polypeptides. The polypeptides have been useful for the assembly of gold nanoparticles, fibrous nanostructures, and for sensing applications.The 42-residue polypeptides are made to fold into helix-loop-helix motifs and dimerize to form four-helix bundles. Folding is primarily driven by the formation of a hydrophobic core made up by the hydrophobic faces of the amphiphilic helices…

Contents: Polypeptide-Based Nanoscale Materials

2 Self-Assembly and Self-Organization
2.1 Supramolecular chemistry
2.2 Bionanotechnology
2.3 Self-assembly of hybrid materials and nanocomposites
3 Peptides, Proteins and Protein Structures
3.1 Structure and folding of proteins
3.2 The alpha-helix
3.3 The four-helix bundle
3.4 Protein adsorption on surfaces
3.5 Determination of protein structure
3.5.1 Infrared spectroscopy
3.5.2 Circular dichroism spectroscopy
4 Polypeptide Design and Synthesis
4.1 The JR-polypeptides
4.2 The KE-polypeptides
4.3 Peptide synthesis
5 Colloidal Gold
5.1 Synthesis of gold nanoparticles
5.2 Optical properties of gold nanoparticles
6 Nanoparticle Stability
6.1 van der Waals forces
6.2 Electrostatic double-layer forces
6.3 Hydration forces and the hydrophobic effect
6.4 Steric- and bridging forces
6.5 DLVO-theory
6.6 Controlling nanoparticle stability using the JR-polypeptides
7 Surface Functionalization of Gold
7.1 Self-assembled monolayers
7.2 Functionalization of gold nanoparticles
7.3 Immobilization of the JR- and KE-polypeptides
7.3.1 Immobilization on planar gold
7.3.2 Immobilization on gold nanoparticles
8 Gold Nanoparticles in Biosensors
8.1 Colorimetric biosensing using KE-polypeptides…

Source: Linköping University

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