Epoxides are three-membered cyclic ethers created in the metabolism of foreign substances and as endogenous metabolites. Epoxide hydrolases (EHs) are enzymes which catalyze the hydrolysis of epoxides to yield the related diols. EHs have been implicated in diverse functions like detoxification of
This dissertation studies synthesis, microstructure and properties of binary and ternary carbide thin films deposited by dc magnetron sputtering. These kind of materials are fascinating as they present an array of useful properties, like high hardness, resistance to wear and oxidation, and
Self-assembly has surfaced as a promising way of fabrication of novel hybrid materials and nanostructures. The work offered in this dissertation has been centered on creating nanoscale materials based on synthetic de novo designed polypeptides. The polypeptides have been useful for the
In every living cell, millions of different types of molecules constantly interact and react chemically in a complex system that can adapt to fluctuating environments and extreme conditions, living to survive and reproduce itself. The information required to produce these components is stored in the genome, which is copied in each cell division and transferred and mixed with another genome from parent to child.
Apatites are a diverse class of phosphate minerals that are important in a great variety of natural and industrial processes. They are, for example, used as raw material in fertiliser production and in the remediation of metal-contaminated soils. Hydroxyapatite Ca5(PO4)3OH, (HAP) and fluorapatite Ca5(PO4)3F, (FAP) are similar to the biological apatite that is the main constituent of mammalian bone and teeth, and they are therefore promising materials for artificial bone and tooth implants.
This thesis describes the application of multivariate methods in a novel approach to the formulation of tablets for direct compression. It begins with a brief historical review, followed by a basic introduction to key aspects of tablet formulation and multivariate data analysis.
The aim of this thesis (Apoptosis Regulation via the Mitochondrial Pathway: Membrane Response upon Apoptotic Stimuli) was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of
The homo and hetero dimerisation of two spectroscopically different chromophores were studied, namely: 4,4-difluoro-4-bora-3a,4a-diazas-indacene (g-BODIPY) and its 5-styryl-derivative (r-BODIPY). Various spectroscopic properties of the r-BODIPY in different common solvents were determined. It was shown that g- and r-BODIPY in the ground state
The Escherichia coli chaperonin GroEL assists in the re-folding of misfolded substrate proteins (SPs). In response to the binding of ATP, GroEL undergoes large, allosteric structural transitions, resulting in an expansion of its central cavity and a capping of the cavity by
In the first part, the preparation and properties of chalcogen-containing vitamin E analogues are described. The sulfur compound 3,3,4,6,7-pentamethyl-2,3-dihydrobenzo[b]thiophene-5-ol was prepared by two different routes using ionic… Contents 1. INTRODUCTION 1.1 Oxygen in biological and polymeric systems 1.1.1 General introduction 1.1.2 Mechanism