Antibiotic resistance is a present problem. Bacteria are becoming more and more immune to well-known antibiotics and we’re experiencing an increasing resistance problem. The present dissertation was directed at researching the effect of antibiotic treatment on pathogenic bacteria along with on the standard human microbiota..
The Escherichia coli chaperonin GroEL assists in the re-folding of misfolded substrate proteins (SPs). In response to the binding of ATP, GroEL undergoes large, allosteric structural transitions, resulting in an expansion of its central cavity and a capping of the cavity by
In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids
Escherichia coli is a natural inhabitant of the intestines of both humans and animals, but there are also several pathogenic types of E. coli which cause disease in humans. Strains of enterohemorrhagic E. coli (EHEC) have been associated with outbreaks of diarrhea,
The aim of the current project was to develop software sensors which probe for important state parameters in batch and fed-batch cultivations and which enable to control processes in a more advanced and effective way. Software sensors are a potent tool to
The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation.