Antibiotic resistance is a present problem. Bacteria are becoming more and more immune to well-known antibiotics and we’re experiencing an increasing resistance problem. The present dissertation was directed at researching the effect of antibiotic treatment on pathogenic bacteria along with on the standard human microbiota..
The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation.
In cardiac surgery, sternal wound infection (SWI) continues to be one of the most serious postoperative complications. Coagulase-negative staphylococci (CoNS) have become the most common causative agents of SWI. Prophylaxis with intravenous beta-lactam antibiotics (cephalosporins or in Sweden most commonly isoxazolyl penicillins)